Therefore, it is tempting to speculate that long term consumption of EVOO containing this compound may contribute to significantly reduce the development and/or the progression of chronic inflammatory diseases and to increase the response to biological agents, thus representing a nutritional marker of responsiveness to Tumor Necrosis Factor-α blockers in psoriasis, in association with genetic marker, such as Interleukin 6 gene promoter polymorphism [45]. This evidence concerns the gene TNF and psoriasis.