IL2 and non-small cell lung carcinoma: Here we report on a composite of a preclinical animal study and a phase Ib trial in metastatic NSCLC to test the systemic effect of the immunocytokine NHS-IL2 and radiotherapy in an animal model, and determine safety and tolerability of NHS-IL2 in combination with radiotherapy in metastatic NSCLC directly following first-line palliative chemotherapy.