In the pathophysiology of cancer, increased expression of HMGB1 and RAGE is associated with proliferative activity and metastatic potential in many types of tumors, including breast cancer [19], hepatocellular carcinoma [8], melanoma [20], glioma [21, 22], prostate cancer [23], gastric cancer [24], and colorectal cancer [25–27]. Here, HMGB1 is linked to cancer.