In oral cancer, HMGB1 has been reported to promote lymphangiogenesis through the upregulation of vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D) [44], which might be linked to the transmigration of HMGB1 [27]. The gene discussed is VEGFD; the disease is lip and oral cavity carcinoma.