However, there was a notable reduction in the tumor growth- rate when MF or ICI was added to the cisplatin/radiation scheme, suggesting that MF and ICI play an important role in the chemo-radiosensitization not only in- vitro but also in- vivo. When we evaluated the VEGF expression in the xenografts at the end of the study, we observed that both antihormonal agents decrease VEGF production. This evidence concerns the gene VEGFA and neoplasm.