Our aims were 1) to explore the relationship between the CD14 C-260T SNP on markers of monocyte/macrophage activation (including soluble(s) CD14 and sCD163) and inflammation (as measured by highly sensitive C-reactive protein (hsCRP) and 2) to assess the association between the CD14 C-260T SNP and subclinical atherosclerosis measured by carotid intima-media thickness (cIMT). The gene discussed is CD14; the disease is atherosclerosis.