To explore the molecular mechanism of LASP1 on tumor progression, Wang et al. analyzed in SW480 and HCT116 cell lines the effect of LASP1 on proteins involved in the epithelial-mesenchymal transition (EMT), a process by which epithelial cells lose their cell polarity and cell-cell adhesion and gain migratory and invasive properties. The gene discussed is LASP1; the disease is neoplasm.