Via its SH3 domain, LASP1 directly binds to proline-rich domains of several other proteins, namely zyxin [15], the LIM domain containing preferred translocation partner in lipoma (LPP; a shuttle protein and transcription factor) [16], vasodilator-stimulated phosphoprotein (VASP, an actin binding partner) [10,17], palladin (140kDa isoform) [18], dynamin [19], and zonula occludens protein 2 (ZO-2) [20], with zyxin being the most prominent interaction partner. The gene discussed is ZYX; the disease is lipoma.