Additionally, in hepatocellular carcinoma (HCC) LASP1 expression, cytoplasmic as well as nuclear, was increased compared to adjacent non-tumoral tissue and was correlated with hepatitis B surface antigen and serum alpha-fetoprotein level of HCC patients [77], suggesting a link between LASP1 and tumorigenesis upon viral hepatitis. This evidence concerns the gene AFP and hepatocellular carcinoma.