MiR-21 was recently suggested to play a part in resistance to the CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen in DLBCL, as its knockdown in CRL2631 cells increased the sensitivity to treatment via phosphatase and tensin homolog (PTEN) upregulation [130]. This evidence concerns the gene PTEN and diffuse large B-cell lymphoma.