The EPB41L3 gene (DAL-1/4.1B: differentially expressed in adenocarcinoma of the lung) is located in the 18p11.3 region and codes for an adhesion protein belonging to the 4.1 family of membrane-associated proteins, which is strongly expressed in the brain [9, 10] and also regulates cell growth [11]. The gene discussed is EPB41L3; the disease is lung adenocarcinoma.