Our analysis of published tumor microarray data found S1P2 mRNA to be significantly reduced in PDAC (Buchholz et al., 2005; Segara et al., 2005; Badea et al., 2008), and some lung and colon tumors (Bhattacharjee et al., 2001), compared to their corresponding normal tissues. This evidence concerns the gene S1PR2 and neoplasm.