Here, master regulators appear active, as delineated for anoikis induction in pancreatic cancer cells (Capan-1) in vitro by tumor suppressor p16INK4a via upregulation of Gal-1 (the lectin) and the fibronectin receptor (also termed α5β1-integrin, the protein scaffold) as well as the downregulation of sialic acid biosynthesis to increase responsiveness to Gal-1 by reducing α2,6-sialylation, a block to Gal-1 binding [73,128]. Here, LGALS1 is linked to familial pancreatic carcinoma.