TP53 and cancer: To examine the effect of MDM4 and MDM2 knockdown on the growth of wt TP53 cancer cells, we tested the 11 previously mentioned wt TP53 cancer cell lines, which included seven with high levels of MDM4 expression (MCF-7, A375, SNU-1, HCT116, NUGC-4, LoVo, and A549) and four with low levels of MDM4 expression (SJSA-1, HepG2, HuH-6, and C32TG).