ALDH18A1 and Familial prostate cancer: Overexpression of c-Myc in P493 human Burkitt lymphoma and PC3 human prostate cancer induced an upregulation of PYCR1 expression as well as the P5C biosynthetic enzyme delta-1-pyrroline-5-carboxylate synthase (P5CS), resulting in higher levels of intracellular proline [41].