Few previous studies have investigated the association between VEGF −2578C/A, −1154G/A and −634C/G polymorphisms and the prognosis of RCC patients (17–19), thus, the present study is, to the best of our knowledge, the first to identify that the VEGF −2578C/A polymorphism is associated with the prognosis of RCC patients, as well as demonstrating an interaction with the tumor stage and size. The gene discussed is VEGFA; the disease is renal cell carcinoma.