MHC class I chain-related genes (MIC)A and MICB are important regions of the NKG2D ligands that are expressed in human cancer cells, Huang et al demonstrated that a combination of histone deacetylase inhibitors, to upregulate cell surface MICA/B in certain tumors, with metalloproteinase inhibitors to block MICA/B shedding can regulate cell-surface MICA/B levels, and eventually lead to significantly enhanced the anti-tumor activity of CIK cells (33). This evidence concerns the gene MICA and cancer.