MAPT and Alzheimer disease: However, there was no HSP 27 immunostaining of senile plaques or neurofibrillary tangles within the frontal and temporal cortices and the hippocampus in patients with AD, nor was there HSP 27 immunostaining of Pick bodies in patients with FTLD-tau, or TDP- 43 immunoreactive neuronal cytoplasmic inclusions in patients with F TLD-TDP, or MND (not shown).