Using a rabbit anti-HSP27 antiserum raised against a hybrid protein containing the N-terminal part of the murine HSP27 (amino acids 1 to 110) and the C-terminal part of the human HSP27 (amino acids 111 to 208), Renkawek and co-workers showed a highly induced expression of HSP27 in many proliferating astrocytes in affected regions of cerebral cortex, especially in those areas rich in senile plaques [12]. The gene discussed is HSPB1; the disease is Senile plaques.