Comparisons of the FTLD (overall), AD, MND and control groups showed significant differences in the severity of HSP27 rating values for neurons (F(3, 162) =10.7, P =0.013), grey matter glial cells (F(3, 162) =21.7, P =0.000) and white matter glial cells (F(3, 162) =25.8, P =0.000) of the temporal cortex, and for neurons (F(3, 151) =18.9, P =0.001), grey matter glial cells (F(3, 151) =29.2, P =0.000) and white matter glial cells (F(3, 151) =46.0, P =0.000) of the frontal cortex. This evidence concerns the gene HSPB1 and mild neurocognitive disorder.