Mice heterozygous for Alk1 or Eng, or conditionally deleted for either of these genes in endothelial cells, represent animal models for HHT (Srinivasan et al., 2003; Torsney et al., 2003; Park et al., 2009; Mahmoud et al., 2010). The gene discussed is ENG; the disease is hereditary hemorrhagic telangiectasia.