RECQL and neoplasm: The results showed that RECQL1-targeted siRNA can suppress tumor growth in many mouse xenograft models, including lung, liver, pancreatic, colorectal cancer models and in orthotropic hepatic cancer models (Figure 2A), as well as in nude mice that have head and neck carcinoma (Futami et al., 2008a,c, 2010; Arai et al., 2011).