Early-life infection generally leads to a direct elevation of circulating glucocorticoids in early-life (Bilbo et al., 2005a) and while basal CORT was not affect by early-life infection at P14, the level of phosphorylated GR is significantly higher in the prefrontal cortex, but not the hippocampus (Dinel et al., 2014). This evidence concerns the gene NR3C1 and infection.