This potential pathogenetic role of Cav1.3 hyperactivity for brain disease is further strengthened by previous finding of two other Cav1.3 channel-activating mutations (e.g., I750M; see further on) reported to cause PASNA, a severe syndrome with neurodevelopmental deficits and seizures at an early age (22,23). Here, CACNA1D is linked to aldosterone-producing adenoma with seizures and neurological abnormalities.