In the present study we therefore determined whether older people chronically prescribed statins and reporting myalgia symptoms presented with (1) reduced muscle mass, strength and work output during repeated maximal contractions and (2) elevated leg protein breakdown in the fasted state and, when exposed to a ‘fed state’ (hyperaminoacideamia, hyperinsulinaemia) clamp, and showed (3) a blunted increase in muscle protein synthesis and dampened decrease in muscle protein breakdown and (4) insulin resistance compared to age‐matched control volunteers. Here, INS is linked to Myalgia.