The overexpression of Cyr61 in ESCC tissues has been reported to be associated with poor survival of ESCC patients, although there was no association between Cyr61 expression and clinicopathological variables including histological grade, clinical stage, and lymph node metastasis.33,35 We also confirmed that the overall expression levels of Cyr61 showed a significant positive correlation with only lymph node metastasis in our series of ESCC cases. Here, CCN1 is linked to metastatic malignant neoplasm in the lymph nodes.