NF-κB, Stat3, Stat6, c-myc, and interferon regulatory factor are involved in skewing to the M2 phenotype of macrophages.36–39 Among them, it is well known that Stat3 is an important transcription factor in the interaction between TAMs and tumor cells.40–42 However, the distinct pathway of CD204 expression in macrophages is not completely understood. The gene discussed is STAT6; the disease is neoplasm.