CCN1 and cancer: We were also interested in upregulated genes known to be induced in M2 macrophages (Table2).19 Among these genes, we decided to focus on CYR61, known to promote not only macrophage polarization but also cell proliferation, invasion, survival, and metastasis of various cancers.20–22CYR61 was highly induced (22.78-fold) by TE-8CM.