PCR analysis of control (SAH) and experimental (SAM) treated LM-7 cells showed a marked inhibition in the expression of tumor-promoting genes (MMP-2, MMP-9, VEGF, PAI-1, and uPA) and genes (uPA, TFG-β, and RUNX2) which are known to promote the development and progression of skeletal metastasis. Here, SERPINE1 is linked to neoplasm.