In studies of uromodulin knock-out mice, Mutig et al. [63] showed that activation of NKCC2 is facilitated by uromodulin in a Cl−-sensitive manner, which is interesting as there is now an accrual of data from human genome-wide association studies and rodent studies that uromodulin is associated with hypertension and salt sensitivity [24, 72, 90]. This evidence concerns the gene UMOD and Hypertension.