GATA2 and acute myeloid leukemia: Pedigree studies have initially recognized two mutations in GATA2 in familial AML, p.T354M, and p.T355del, both in the second zinc finger (ZF-2) of GATA216–18, while two other mutations; p.R308P and p.A350-N351ins8 are associated with de novo AML 78.