IGF-axis protein expression was a predictor of mortality risk in Native Hawaiian breast cancer patients—a group who suffer disparately high incidence and mortality rates for this cancer.5 In Native Hawaiian patients, IGFBP2 and IGFBP3 were each independently associated with all-cause and breast cancer-specific mortality, and IGF1R was associated with death from all causes. This evidence concerns the gene IGFBP3 and cancer.