IGF-axis protein expression was a predictor of mortality risk in Native Hawaiian breast cancer patients—a group who suffer disparately high incidence and mortality rates for this cancer.5 In Native Hawaiian patients, IGFBP2 and IGFBP3 were each independently associated with all-cause and breast cancer-specific mortality, and IGF1R was associated with death from all causes. The gene discussed is IGFBP3; the disease is breast carcinoma.