CDKN2A and neoplasm: When analyzed separately, we observed an increase in expression of p16(INK4A) in both tumor and adjacent normal tissues from HPV+ OPSCC compared to HPV− OPSCC (Wilcoxon rank sum test P = 0.007 and P = 0.006, respectively), but little difference in overall expression of p16(INK4A) between tumor and adjacent normal samples within the same subject for either HPV+ or HPV− OPSCC cases.