When mining gene expression data from our head and neck cancer genomics database, HPV+ OPSCC tumors showed a significant increase in the expression of DNA methyltransferase 1 (DNMT1), the major eukaryotic DNA methyltranferase (unpaired t-test with Welsch correction, P < 0.001) (Fig.1A) supporting our observation of increased DNA methylation in these tumors 11. This evidence concerns the gene DNMT1 and head and neck cancer.