Moderate AST or ALT >2.5 times but ≤5 times ULN, or moderate total bilirubin elevation >1.5 times but ≤3 times ULN: withhold ipilimumab dose Severe AST or ALT elevations of >5 times ULN; total bilirubin elevations of >3 times ULN; or failure to complete full treatment course within 16 weeks from administration of first dose: permanently discontinue ipilimumab Grade ≥3 hepatitis: consider corticosteroid therapy. This evidence concerns the gene GPT and Hepatitis.