Underscoring the potential importance of α7 nAChR in humans, it has been shown that leukocytes and fibroblast-like synoviocytes (FLS) in the RA synovium express α7 nAChR and α7 nAChR-specific agonists can, in vitro, modulate the inflammatory response of RA FLS [15,16]. Here, CHRNA7 is linked to rheumatoid arthritis.