Genes in these four sets included: (1) genes involved in the process preventing the degeneration of the photoreceptor (a specialized cell type that is sensitive to light), (2) genes down-regulated in prostate tumor (a tumor with distinct signatures differentiate between African-American and European-American patients [19]), (3) genes associated with malignant fibrous histiocytoma tumors, and (4) genes up-regulated in colon tissue upon the knockout of MBD2, a methyl-CpG binding protein that mediates the methylation signal. This evidence concerns the gene MBD2 and prostate neoplasm.