In this context, it is worth noting that Tls (one of the genes causing amyotrophic lateral sclerosis in human) had been already the focus of previous works in the retina, given that its overexpression led to progressive photoreceptor degeneration in Drosophila (Chen et al., 2011), and that TLS is involved in the regulation of the receptor of the NMDA neurotransmitter in rat ganglion retinal cells (Selamat et al., 2009). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.