SOCS3 and metabolic dysfunction-associated steatohepatitis: Socs3 has also been demonstrated in several studies to be an important mediator of both murine and human NASH (Prpic et al. 2003; Bergen et al. 1999; Parekh et al. 1998; Surwit et al. 1997; Winzell and Ahren 2004; Livingston et al. 1994; Surwit et al. 1988; Tilg 2010; Sachithanandan et al. 2010; Surwit et al. 1995; Watson et al. 2000).