PNPLA3 and fatty liver disease: Overexpression of the PNPLA3 I148M polymorphism in mice also causes hepatic steatosis and PNPLA3 has been shown to regulate hepatic lipid metabolism (Basantani et al. 2011; Chen et al. 2010; Li et al. 2012; Ruhanen et al. 2014; Singal et al. 2014; Said 2013; Pingitore et al. 2014; Krawczyk et al. 2013; Peng et al. 2012; Santoro et al. 2010; Rotman et al. 2010; Speliotes et al. 2010; Zain et al. 2012).