In addition, several studies have also demonstrated the important role of Socs3 in the pathogenesis of nonalcoholic steatohepatitis, regulating insulin sensitivity, leptin signaling, glucose metabolism, lipogenesis, and fatty liver (Wang et al. 2009; Ihle 1995; Muraoka et al. 2003; Kievit et al. 2006; Howard et al. 2004; Dittrich et al. 2012; Sachithanandan et al. 2010). Here, LEP is linked to metabolic dysfunction-associated steatohepatitis.