In patients treated with metformin, similar risk profile for MI, HF or stroke were observed in the EBID and EBID + insulin group, compared to those in the insulin group - the HR (95% CI; p) for composite of MI or stroke for EBID and EBID + insulin groups was 0.54 (0.34, 0.88; p = 0.012) and 0.44 (0.33, 0.59; p < 0.01) respectively. The gene discussed is INS; the disease is Stroke.