PGR and cancer: Migliaccio et al. (2007) reported that estrogens may signal through intracellular effectors such as c-Src, which in turn activate complex transduction networks leading to gene expression changes in cancer cells. Hence, we used the c-Src inhibitor PP2 to evaluate the involvement of c-Src in gene transcription stimulated by atrazine and E2 in BG-1 cells (see Supplemental Material, Table S3) and 2008 cells (data not shown). The up-regulation of PR, pS2, and cyclin A induced by E2 was decreased in the presence of PP2, although the induction of these genes still remained statistically significant.