We have previously shown that VGLUT2-mediated transmission from Trpv1-Cre neurons is responsible for acute heat transmission [10] and heat hyperalgesia associated with inflammation [13] and our novel finding indicates that VGLUT2-mediated glutamatergic transmission from Trpv1-Cre neurons is also responsible for mediating heat hyperalgesia associated with peripheral nerve injury. Here, TRPV1 is linked to peripheral nerve injury.