The resultant clones, EMT6/EF-Luc/UCHL1 and EMT6/EF-Luc/EV cells, showed that the forced expression of UCHL1 induced the expression of HIF-1α and HIF-1 activity (Supplementary Fig. 10a,b) and enhanced cell migration (Supplementary Fig. 11), but did not promote cell proliferation in vitro, EF-Luc reporter activity or the growth of tumour xenografts following subcutaneous transplantation (Supplementary Fig. 10c–e). This evidence concerns the gene UCHL1 and neoplasm.