2011 and Madden et al. 2009; inversions flanked by deletions in intronic sequence are proposed to be a result of replication-based mechanisms (Madden et al. 2009; Khelifi et al. 2011). In a patient with DMD with a dup-trip/inv-dup Ishmukhametova et al. (2013) described a two-step model where inverted repeats facilitate break-induced replication followed by NHEJ. Other observed CGRs in DMD were shown to be noncontiguous duplications and triplications (White et al. 2006; Zhang et al. 2008; Oshima et al. 2009). Here, DMD is linked to Duchenne muscular dystrophy.