Eighty-seven previously unpublished predicted pathogenic mutations were identified in the MPZ (18), SH3TC2 (14), GJB1 (12), GDAP1 (9), FIG4 (7), PMP22 (7), PRX (7), MFN2 (6), GARS (3), HSPB1 (2), and NEFL (2) genes clearly documenting the contributions of rare variants to neuropathy. The gene discussed is NEFL; the disease is neuropathy.