The pathology specimen from the initial operation was re-evaluated and was shown to contain periodic acid-Schiff (PAS) positivity and ACTH immunoreactivity in a pattern consistent with a sparsely granulated corticotrope adenoma (Fig. 2); staining for Pit1 and GH was completely negative and the pattern of keratins decorated with the Cam 5.2 antibody was intense and diffuse in the cytoplasm, consistent with corticotropes rather than somatotropes. The gene discussed is POMC; the disease is adenoma.