Studies performed on in silico subjects created from mathematical models for prediction of glucose concentrations in subjects with type 1 diabetes have suggested that the super bolus, or other strategies of combining basal and bolus insulin, could be habitually used instead of conventional bolus therapy, as they provide more effective control of postprandial hyperglycemia without increasing the risk of postabsorptive hypoglycemia (3). The gene discussed is INS; the disease is Hypoglycemia.