Notably, the frequencies of IFN-γ-producing tumor-reactive CD8 T cells from anti-PD-L1/CTLA4 treated mice were similar to those treated with the anti-PD-L1/LAG-3 and anti-PD-L1/TIM-3 combinations (Figures 4A and 5B). The gene discussed is CTLA4; the disease is neoplasm.