Common features of the top three pathways for KD (Trem1 signaling, Hepatic fibrosis, and IL-10 signaling) and the other groups were the abundance of transcripts related to the activation of the Nlrp3 inflammasome, including Il-1 and caspase-1 related transcripts (Figure 5). The gene discussed is CASP1; the disease is Hepatic fibrosis.