PPARGC1A and type 2 diabetes mellitus: For this study, we used a subset of baseline muscle samples from the Health Benefits of Aerobic and Resistance Training in Type 2 Diabetes (HART-D) study [14] to define the relationship between the −1N position in PGC1α, FLPGC1α, and NTPGC1α splice variant expression in skeletal muscle and cardiometabolic risk factors in overweight/obese individuals with T2D.