We mapped the −1N within the PGC1α promoter region to provide insight into differential epigenetic regulation of PGC1α, including FLPGC1α and NTPGC1α splice variant expression, in overweight/obese individuals with T2D and to provide evidence that alterations in PGC1α  −1N position and splice variant expression are associated with differential CVD risk [10]. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.