IL1B and Neonatal sepsis: Tumor necrosis factor (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) are proinflammatory cytokines, whereas interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β) are known as anti-inflammatory cytokines, both produced rapidly in the setting of neonatal sepsis.