The study of proinflammatory cytokines IL-6, TNF-α, IL-1β, and IL-8 and anti-inflammatory cytokines IL-10 and TGF-β as reliable biomarkers of neonatal infection has been shown to be potentially useful for early sepsis diagnosis and to predict the severity of disease at early stages of the infection [23–26]. This evidence concerns the gene IL1B and Sepsis.