PLCE1 and esophageal squamous cell carcinoma: In 2010, Abnet et al firstly performed a GWAS of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in Chinese populations and identified variants located in the PLCE1 gene at chromosome 10q23 had a genome-wide significantly correlation with gastric cardia cancer (GCA) and ESCC5.