PLCE1 and esophageal squamous cell carcinoma: Furthermore, in the stratified analysis by HWE in controls, we found a significant increased association between PLCE1 rs2274223 polymorphism and ESCC risk in the studies consistent with HWE (G vs. A: OR = 1.29, 95% CI = 1.13–1.47; GG vs. AA: OR = 1.62, 95% CI = 1.21–2.15; GA vs. AA: OR = 1.32, 95% CI = 1.19–1.46; GG/GA vs. AA: OR = 1.37, 95% CI = 1.20–1.56; GG vs. GA/AA: OR = 1.42, 95% CI = 1.10–1.83) (Table 3).