Only when stratified for MSI status, was a correlation observed with a higher rate of nuclear beta-catenin in PRDM5 methylated compared to unmethylated BRAF mutant/MSI cancers (13/21, 62% vs 12/38, 32%) (p = 0.03) (Additional file 1: Table S2). The gene discussed is PRDM5; the disease is cancer.