This minimal PRDM5 methylation rate in BRAF wild type cancers, at 3%, was similar to the low frequency found in the one other study that investigated primary colorectal cancers [4], and others have concluded that there is only a negligible rate of PRDM5 methylation in colorectal cancer based on cell line analysis [8]. The gene discussed is PRDM5; the disease is colorectal cancer.