Previous findings have shown that PRDM5 can interact with a variety of genes involved in inhibition of the Wnt pathway [6], PRDM5 loss results in an increased number of intestinal adenomas on an upregulated Wnt background [10], and methylated PRDM5 has been correlated with presence of active beta-catenin in cancer cell lines [8]. This evidence concerns the gene CTNNB1 and cancer.