CIMP high was strongly prevalent in the BRAF mutant/MSI cancers (at 86%), therefore this was evident in the BRAF mutant/MSS cohort (61% CIMP high rate) where CIMP high was more frequent in PRDM5 methylated compared to unmethylated cancers (27/36, 75.0% vs 27/53 50.9%; p = 0.03) (Additional file 1: Table S2). This evidence concerns the gene PRDM5 and cancer.