PTEN and cancer: Pertinent hereditary cancer syndromes include Peutz-Jeghers (STK11), Li-Fraumeni (TP53), Lynch (MLH1, MSH2, MSH6, PMS2, EPCAM, MUTYH) and Cowden (PTEN) syndromes, as well as hereditary diffuse gastric cancer (CDH1).109 In the latter disorder, a hypomethylating drug is being considered to prevent cancer progression from premalignant lesions by thwarting CDH1 promoter methylation.