SLC3A2 and diffuse large B-cell lymphoma: However, one should be aware that about 15% of lower grade LyG can progress to malignant lymphoma.87 PCR analysis for Ig heavy chain gene rearrangement demonstrated a monoclonal pattern.88 Grade III LyG patients are treated with similar regimens used for DLBCL and DA-EPOCH-R has been reported to be effective with 66% complete remission.