The temporal pattern differed significantly for each marker between the patient groups; levels in patients with infection were significantly elevated (LBP 12 h: P = 0.001, 24 h: P <0.001, 3 d: P = 0.007; IL-10 6 h: P = 0.006, 12 h: P <0.001, 24 h: P = 0.004; IL-6 6 h: P <0.001, 12 h: P <0.001, 24 h: P = 0.004, 3 d: P = 0.003, 7 d: P = 0.008; CRP 6 h: P = 0.007, 12 h: P <0.001, 24 h: P <0.001, 3 d: P <0.001, 7 d: P = 0.002). The gene discussed is IL6; the disease is infection.