MTOR and renal cell carcinoma: Another HDAC inhibitor, SAHA, reduced the proliferation of RCC cells and augmented the activity of the mTOR inhibitor temsirolimus to induce apoptosis in xenografted RCC cell lines and depsipeptide-induced apoptosis in Caki-1, ACHN, and 786O cells, and induced G2 cell cycle arrest in 769P cells [17,31,32].