Another study found truncating mutations in the PBRM1 gene, which encodes the Baf180 protein, a chromatin-targeting subunit of the SWI/SNF chromatin remodeling complex that has been implicated in multiple chromatin/transcriptionally mediated processes through interaction with histone H3, in 41% of RCC cases [26]. Here, SMARCA1 is linked to renal cell carcinoma.