MALAT1 is located on 11q13 of the human genome, which has been verified to be frequently amplified in ESCC tissues [42,43], and recent studies have discovered the tight correlation between lncRNAs amplification with their expression level [44,45], we then detected the genomic copy number of MALAT1 in the 54 tumor tissues mentioned above by a newly developed method AccuCopyTM, which has been applied in other excellent works, and proven to be efficient and accurate [25,46]. Here, MALAT1 is linked to esophageal squamous cell carcinoma.